MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is a mitochondria-derived compound encoded within the 12S rRNA gene of mitochondrial DNA. It acts as a mitochondrial signaling molecule that regulates metabolic homeostasis by activating AMPK pathways, enhancing insulin sensitivity, and improving cellular energy utilization. Research suggests MOTS-c plays a key role in metabolic flexibility, exercise response, and age-related metabolic decline, positioning it as a novel target in longevity and metabolic dysfunction studies.
Research Use Only. Not for human consumption.
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